Vertigo Research Today is a free monthly online journal that collates and summarizes the latest research about Vertigo, including details on causes, symptoms, treatment, dizziness. | ||||||
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Proteomics in Ménière disease.Chiarella G, Saccomanno M, Scumaci D, Gaspari M, Faniello MC, Quaresima B, Di Domenico M, Ricciardi C, Petrolo C, Cassandro C, Costanzo FS, Cuda G, Cassandro E Department of Experimental and Clinical Medicine, Audiology and Phoniatrics Unit, "Magna Graecia" University, Catanzaro, Italy. chiarella@unicz.it. Ménière's disease (MD) is a disorder of the inner ear characterized by an insidious onset and aspecific symptoms, such as dizziness, vertigo, tinnitus, and hearing loss, that may become very debilitating. The presence of endolymphatic hydrops is a common feature in MD patients, but the pathophysiology is still largely unknown. In this study, we have used a proteomics-driven approach to identify potential biomarkers of MD. To this end, plasma was obtained from whole blood of 16 individuals previously diagnosed as suffering from MD and compared to plasma from healthy donors. A depletion of the highly abundant proteins (i.e. albumin, IgG, transferrin, etc.) was performed in order to enhance the chance of detection of the less represented ones, therefore reducing the noise-background. Two-dimensional gel electrophoresis, followed by in-gel tryptic digestion of the selected spots and LC-MS/MS analysis, allowed us to identify a set of proteins whose expression appears to be differentially modulated in patients vs. controls. In particular: complement factor H and B, fibrinogen alpha and gamma chains, beta-actin and pigment epithelium derived factor are over expressed; on the other hand, the levels of beta-2 glycoprotein-1, vitamin D binding protein and apolipoprotein-1 are significantly decreased in the plasma of MD-affected individuals. Even though preliminary and not necessarily linked directly to the molecular pathogenesis of the disease, our original findings suggest that a molecular signature, represented by the plasma protein profile previously described, might represent a potentially powerful, innovative and not invasive tool for early diagnosis and clinical management of MD patients. © 2011 Wiley Periodicals, Inc. Published 6 May 2011 in J Cell Physiol. Articles on Vertigo published 29 April 2011: Identifying the affected branches of vestibular nerve in vestibular neuritis. Acta Otolaryngol. Abstract Conclusion. The inner ear monitoring system is useful for identifying the affected branches of the vestibular nerve in cases of vestibular neuritis, providing insight about the interval for the relief of vertigo. Objective: This study conducted an inner ear monitoring system including audiometry, and caloric, ocular vestibular evoked myogenic potential (oVEMP), and cervical VEMP (cVEMP) tests in cases of vestibular neuritis for assessing the affected branches of the vestibular nerve. ... [Abstract] [Full-text] Spontaneous nystagmus in benign paroxysmal positional vertigo. Am J Otolaryngol, 32(3): 185-9. Articles on Vertigo published 28 April 2011: ED patients with vertigo: can we identify clinical factors associated with acute stroke? Am J Emerg Med. BACKGROUND: Vertigo is a common emergency department (ED) complaint with benign and serious etiologies with overlapping features. Misdiagnosis of acute stroke may result in significant morbidity and mortality. Magnetic resonance imaging (MRI) is superior to computer tomography (CT) for diagnosis of acute stroke but is costly with limited availability. OBJECTIVE: The aim of this study was to identify clinical characteristics associated with a cerebrovascular cause for vertigo. METHODS: We ... [Abstract] [Full-text] Elevated coherent motion thresholds in mild traumatic brain injury. Optometry, 82(5): 284-9. Articles on Vertigo published 27 April 2011: Syphilitic myositis: a case-based review. Clin Rheumatol, 30(5): 729-33. To present the clinical and pathological findings in patients presenting with myositis caused by syphilis. The literature is reviewed, and pathophysiologic factors discussed. A 49-year-old Caucasian heterosexual male with a known history of stable human immunodeficiency virus (HIV) and hepatitis C (HCV) co-infection, developed progressive muscle weakness over 10 weeks. He discontinued his medications; however, he had on-going muscle symptoms. A muscle biopsy was performed, consistent with mild ... [Abstract] [Full-text] Articles on Vertigo published 26 April 2011: Historical sources of basilar artery occlusion. Neurology, 76(17): 1520-3. Posterior circulation stroke, which includes basilar artery occlusion (BAO), accounts for approximately 20% of all ischemic strokes. Much is unclear concerning the early historical descriptions of basilar artery occlusion, and some modern authors cite the historical sources incorrectly and incompletely. The case described by the Scottish physician John Abercrombie in 1828 is probably the first description of this form of stroke. The progressive bulbar signs that Abercrombie described in his ... [Abstract] [Full-text] Effects of estradiol-drospirenone hormone treatment on carotid artery intima-media thickness and vertigo/dizziness in postmenopausal women. Arch Gynecol Obstet, 283(5): 1045-51. Articles on Vertigo published 25 April 2011: Risk factors for geriatric patient falls in rehabilitation hospital settings: a systematic review. Clin Rehabil. Objective: To review the literature to identify and synthesize the evidence on risk factors for patient falls in geriatric rehabilitation hospital settings. Data sources: Eligible studies were systematically searched on 16 databases from inception to December 2010. Review methods: The search strategies used a combination of terms for rehabilitation hospital patients, falls, risk factors and older adults. Cross-sectional, cohort, case-control studies and randomized clinical trials (RCTs) ... [Abstract] [Full-text] © 2005-2011 Vertigo Research Today. All Rights Reserved. |
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