Vertigo Research Today is a free monthly online journal that collates and summarizes the latest research about Vertigo, including details on causes, symptoms, treatment, dizziness.

Histamine H1 receptors are expressed in mouse and frog semicircular canal sensory epithelia.

Botta L, Tritto S, Perin P, Laforenza U, Gastaldi G, Zampini V, Zucca G, Valli S, Masetto S, Valli P

aDepartment of Physiological-Pharmacological Cellular-Molecular Sciences, University of Pavia bDepartment of Experimental Medicine, Section of Human Physiology, University of Pavia, Italy.

Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders. Their site and mechanism of action, however, are still poorly understood. To increase our knowledge of the histaminergic system in the vestibular organs, we have investigated the expression of H1 and H3 histamine receptors in the frog and mouse semicircular canal sensory epithelia. Analysis was performed by mRNA reverse transcriptase-PCR, immunoblotting and immunocytochemistry experiments. Our data show that both frog and mouse vestibular epithelia express H1 receptors. Conversely no clear evidence for H3 receptors expression was found.

Published 21 February 2008 in Neuroreport, 19(4): 425-9.
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